Version 5.4
Homo sapiens Gene: CDH18
Summary
InnateDB Gene IDBG-13642.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH18
Gene Name cadherin 18, type 2
Synonyms CDH14; CDH14L; CDH24
Species Homo sapiens
Ensembl Gene ENSG00000145526
Encoded Proteins
IDBP-13644
cadherin 18, type 2
IDBP-13646
cadherin 18, type 2
IDBP-474671
cadherin 18, type 2
IDBP-477183
cadherin 18, type 2
IDBP-480759
cadherin 18, type 2
IDBP-477486
cadherin 18, type 2
IDBP-476490
cadherin 18, type 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:19472951-20575873
Strand Reverse strand
Band p14.3
Transcripts
ENST00000382275 ENSP00000371710
ENST00000274170 ENSP00000274170
ENST00000510297
ENST00000507958 ENSP00000425093
ENST00000506372 ENSP00000424931
ENST00000502796 ENSP00000422138
ENST00000515257 ENSP00000427383
ENST00000511273 ENSP00000425854
ENST00000508350
ENST00000511423
ENST00000507632
ENST00000503132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040420
View Gene Order
ENSBTAG00000037844
Not yet available
Pathways
NETPATH
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.317632 Hs.600289
RefSeq NM_001167667 NM_001291956 NM_001291957 NM_004934 XM_005248228 XM_006714435 XM_006714436 XM_006714437
HUGO
OMIM
CCDS CCDS3889 CCDS54835 CCDS75229
HPRD 04314
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca