Version 5.4
Homo sapiens Gene: TBC1D1
Summary
InnateDB Gene IDBG-13418.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBC1D1
Gene Name TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
Synonyms TBC; TBC1
Species Homo sapiens
Ensembl Gene ENSG00000065882
Encoded Proteins
IDBP-13420
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
IDBP-294880
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
IDBP-365305
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
IDBP-365318
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
IDBP-365322
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
IDBP-477273
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
IDBP-477167
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
IDBP-474010
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
IDBP-808021
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:37891087-38139175
Strand Forward strand
Band p14
Transcripts
ENST00000261439 ENSP00000261439
ENST00000402522 ENSP00000383994
ENST00000401554
ENST00000407365
ENST00000406664
ENST00000405444
ENST00000446803 ENSP00000396877
ENST00000443855 ENSP00000397640
ENST00000421339 ENSP00000410167
ENST00000508802 ENSP00000423651
ENST00000491553
ENST00000510573 ENSP00000421641
ENST00000513936 ENSP00000425655
ENST00000509761
ENST00000469803
ENST00000511238
ENST00000475531
ENST00000492180
ENST00000615497 ENSP00000478039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
GO:0032880 regulation of protein localization
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 23216
UniGene Hs.176503
RefSeq NM_001253912 NM_001253914 NM_001253915 NM_015173 XM_005262651 XM_006714001
HUGO HGNC:11578
OMIM 609850
CCDS CCDS33972 CCDS58897
HPRD 18161
IMGT
EMBL
GenPept
RNA Seq Atlas 23216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca