Version 5.4
Homo sapiens Gene: NEDD4
Summary
InnateDB Gene IDBG-13236.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEDD4
Gene Name neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Synonyms NEDD4-1; RPF1
Species Homo sapiens
Ensembl Gene ENSG00000069869
Encoded Proteins
IDBP-13240
neural precursor cell expressed, developmentally down-regulated 4
IDBP-373365
neural precursor cell expressed, developmentally down-regulated 4
IDBP-480898
neural precursor cell expressed, developmentally down-regulated 4
IDBP-478235
neural precursor cell expressed, developmentally down-regulated 4
IDBP-481595
neural precursor cell expressed, developmentally down-regulated 4
IDBP-484607
neural precursor cell expressed, developmentally down-regulated 4
IDBP-479451
neural precursor cell expressed, developmentally down-regulated 4
IDBP-478432
neural precursor cell expressed, developmentally down-regulated 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:55826922-55993746
Strand Reverse strand
Band q21.3
Transcripts
ENST00000338963 ENSP00000345530
ENST00000435532 ENSP00000410613
ENST00000508342 ENSP00000424827
ENST00000508871 ENSP00000422455
ENST00000503468 ENSP00000426051
ENST00000506154 ENSP00000422705
ENST00000502612 ENSP00000424471
ENST00000514893
ENST00000507063 ENSP00000421047
ENST00000513957
ENST00000508075
ENST00000557845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 333 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 333 [view]
Protein-Protein 333 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0019871 sodium channel inhibitor activity
GO:0019904 protein domain specific binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0043130 ubiquitin binding
GO:0050815 phosphoserine binding
GO:0050816 phosphothreonine binding
GO:0070063 RNA polymerase binding
GO:0070064 proline-rich region binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002250 adaptive immune response
GO:0003151 outflow tract morphogenesis
GO:0003197 endocardial cushion development
GO:0006513 protein monoubiquitination
GO:0006622 protein targeting to lysosome
GO:0007041 lysosomal transport
GO:0007528 neuromuscular junction development
GO:0010766 negative regulation of sodium ion transport
GO:0010768 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016567 protein ubiquitination
GO:0019089 transmission of virus
GO:0019221 cytokine-mediated signaling pathway
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175 neuron projection development
GO:0031623 receptor internalization
GO:0032801 receptor catabolic process
GO:0034644 cellular response to UV
GO:0034765 regulation of ion transmembrane transport
GO:0042110 T cell activation
GO:0042391 regulation of membrane potential
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042921 glucocorticoid receptor signaling pathway
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044111 development involved in symbiotic interaction
GO:0045732 positive regulation of protein catabolic process
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0048514 blood vessel morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0050807 regulation of synapse organization
GO:0050847 progesterone receptor signaling pathway
GO:0051592 response to calcium ion
GO:0070534 protein K63-linked ubiquitination
GO:1901016 regulation of potassium ion transmembrane transporter activity
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0016327 apicolateral plasma membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032216
View Gene Order
ENSBTAG00000013793
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115828
Downregulation of ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_111102
Signal Transduction pathway
REACT_25229
Interferon Signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
erbb4_pathway
ErbB4 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt P46934
TrEMBL
UniProt Splice Variant
Entrez Gene 4734
UniGene Hs.1565 Hs.611783
RefSeq NM_001284338 NM_001284339 NM_001284340 NM_006154 NM_198400
HUGO HGNC:7727
OMIM 602278
CCDS CCDS61644 CCDS10156 CCDS45265 CCDS61643
HPRD 03786
IMGT
EMBL AC009997 AC039057 AK304394 AL832063 AY550969 BC136605 BC144284 BC144285 BC152452 BC152562 CH471082 D42055
GenPept AAI36606 AAI44285 AAI44286 AAI52453 AAI52563 AAT52215 BAA07655 BAG65229 EAW77495
RNA Seq Atlas 4734

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca