InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NDUFA9

Summary

InnateDB Gene

IDBG-13148.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFA9

Gene Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

Synonyms

CC6; CI-39k; CI39k; NDUFS2L; SDR22E1

Species

Homo sapiens

Ensembl Gene

ENSG00000139180

Encoded Proteins

IDBP-13150

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

IDBP-601242

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

IDBP-600089

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

IDBP-596730

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:4649095-4694317

Strand

Forward strand

Band

p13.32

Transcripts

ENST00000266544	ENSP00000266544
ENST00000396655
ENST00000536588	ENSP00000445121
ENST00000539573
ENST00000542369
ENST00000544679
ENST00000535050	ENSP00000440305
ENST00000535726
ENST00000544675
ENST00000540688	ENSP00000439818

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0032403	protein complex binding
GO:0050662	coenzyme binding

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0006694	steroid biosynthetic process
GO:0006814	sodium ion transport
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0005759	mitochondrial matrix
GO:0031966	mitochondrial membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000399

View Gene Order

ENSBTAG00000005465

Not yet available

Pathways

NETPATH

REACTOME

REACT_22393

Respiratory electron transport pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa05010

Alzheimer's disease pathway

hsa00190

Oxidative phosphorylation pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_005002

HUGO

OMIM

CCDS

CCDS8532

HPRD

04832

IMGT

EMBL

GenPept

RNA Seq Atlas