InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAB27A

Summary

InnateDB Gene

IDBG-12971.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB27A

Gene Name

RAB27A, member RAS oncogene family

Synonyms

GS2; HsT18676; RAB27; RAM

Species

Homo sapiens

Ensembl Gene

ENSG00000069974

Encoded Proteins

IDBP-12973

RAB27A, member RAS oncogene family

IDBP-237809

RAB27A, member RAS oncogene family

IDBP-746637

IDBP-746979

IDBP-746448

IDBP-744968

IDBP-747028

IDBP-747821

IDBP-747618

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:55202966-55319113

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000336787	ENSP00000337761
ENST00000396307	ENSP00000379601
ENST00000569493	ENSP00000456059
ENST00000563262	ENSP00000457595
ENST00000568803	ENSP00000457517
ENST00000565972	ENSP00000456536
ENST00000566877	ENSP00000454695
ENST00000564609	ENSP00000455012
ENST00000567380	ENSP00000458127
ENST00000567639
ENST00000565776
ENST00000561545

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0019904	protein domain specific binding
GO:0031489	myosin V binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006605	protein targeting
GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0019882	antigen processing and presentation
GO:0030318	melanocyte differentiation
GO:0032400	melanosome localization
GO:0032402	melanosome transport
GO:0043316	cytotoxic T cell degranulation
GO:0043320	natural killer cell degranulation
GO:0043473	pigmentation
GO:0044267	cellular protein metabolic process
GO:0045921	positive regulation of exocytosis
GO:0051875	pigment granule localization
GO:0051904	pigment granule transport
GO:0071985	multivesicular body sorting pathway

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005622	intracellular
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030141	secretory granule
GO:0030425	dendrite
GO:0030667	secretory granule membrane
GO:0032585	multivesicular body membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0070382	exocytic vesicle

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000032202

View Gene Order

Pathways

NETPATH

REACTOME

REACT_15550

Insulin processing pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.654978

RefSeq

NM_004580 NM_183234 NM_183235 NM_183236 XM_005254576 XM_005254577

HUGO

OMIM

CCDS

CCDS10153

HPRD

04845

IMGT

EMBL

GenPept

RNA Seq Atlas