Version 5.4
Homo sapiens Gene: FOS
Summary
InnateDB Gene IDBG-12957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOS
Gene Name FBJ murine osteosarcoma viral oncogene homolog
Synonyms AP-1; C-FOS; p55
Species Homo sapiens
Ensembl Gene ENSG00000170345
Encoded Proteins
IDBP-12959
FBJ murine osteosarcoma viral oncogene homolog
IDBP-585083
FBJ murine osteosarcoma viral oncogene homolog
IDBP-597189
FBJ murine osteosarcoma viral oncogene homolog
IDBP-589558
FBJ murine osteosarcoma viral oncogene homolog
IDBP-595373
FBJ murine osteosarcoma viral oncogene homolog
IDBP-601970
FBJ murine osteosarcoma viral oncogene homolog
IDBP-600819
FBJ murine osteosarcoma viral oncogene homolog
IDBP-583434
FBJ murine osteosarcoma viral oncogene homolog
IDBP-596494
FBJ murine osteosarcoma viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:75278774-75282230
Strand Forward strand
Band q24.3
Transcripts
ENST00000303562 ENSP00000306245
ENST00000554617 ENSP00000450519
ENST00000556324
ENST00000554212 ENSP00000452443
ENST00000535987 ENSP00000442268
ENST00000555242 ENSP00000452386
ENST00000555686 ENSP00000452590
ENST00000555672 ENSP00000452440
ENST00000557139 ENSP00000451786
ENST00000555347 ENSP00000450886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 186 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 186 [view]
Protein-Protein 134 [view]
Protein-DNA 49 [view]
Protein-RNA 1 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0070412 R-SMAD binding
Biological Process
GO:0001661 conditioned taste aversion
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006306 DNA methylation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007399 nervous system development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0009409 response to cold
GO:0009416 response to light stimulus
GO:0009612 response to mechanical stimulus
GO:0009629 response to gravity
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0030431 sleep
GO:0031668 cellular response to extracellular stimulus
GO:0032496 response to lipopolysaccharide
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0034614 cellular response to reactive oxygen species
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035902 response to immobilization stress
GO:0035914 skeletal muscle cell differentiation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493 response to drug
GO:0045087 innate immune response
GO:0045672 positive regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0060395 SMAD protein signal transduction
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021250
View Gene Order
ENSBTAG00000004322
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_18
IL6 pathway
NetPath_56
Prolactin pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_21326
Activation of the AP-1 family of transcription factors pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_120956
Cellular responses to stress pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa04010
MAPK signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
ar_nongenomic_pathway
Nongenotropic Androgen signaling
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
lysophospholipid_pathway
LPA receptor mediated events
il2_1pathway
IL2-mediated signaling events
ps1pathway
Presenilin action in Notch and Wnt signaling
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
s1p_s1p2_pathway
S1P2 pathway
il12_2pathway
IL12-mediated signaling events
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
erbb1_downstream_pathway
ErbB1 downstream signaling
atf2_pathway
ATF-2 transcription factor network
il12_stat4pathway
IL12 signaling mediated by STAT4
ap1_pathway
AP-1 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
fgf_pathway
FGF signaling pathway
endothelinpathway
Endothelins
bcr_5pathway
BCR signaling pathway
tcrraspathway
Ras signaling in the CD4+ TCR pathway
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hif1_tfpathway
HIF-1-alpha transcription factor network
gmcsf_pathway
GMCSF-mediated signaling events
rhoa_pathway
RhoA signaling pathway
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
foxm1pathway
FOXM1 transcription factor network
hnf3apathway
FOXA1 transcription factor network
pdgfrapathway
PDGFR-alpha signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
telomerasepathway
Regulation of Telomerase
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL H0YJM3
UniProt Splice Variant
Entrez Gene 2353
UniGene Hs.731317
RefSeq NM_005252
HUGO HGNC:3796
OMIM 164810
CCDS CCDS9841
HPRD 01275
IMGT
EMBL AF111167
GenPept
RNA Seq Atlas 2353

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca