Version 5.4
Homo sapiens Gene: TMED10
Summary
InnateDB Gene IDBG-12915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMED10
Gene Name transmembrane emp24-like trafficking protein 10 (yeast)
Synonyms p23; P24(DELTA); S31I125; S31III125; Tmp-21-I; TMP21
Species Homo sapiens
Ensembl Gene ENSG00000170348
Encoded Proteins
IDBP-12917
transmembrane emp24-like trafficking protein 10 (yeast)
IDBP-598743
transmembrane emp24-like trafficking protein 10 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex\'s gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer\'s disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:75131470-75176631
Strand Reverse strand
Band q24.3
Transcripts
ENST00000303575 ENSP00000303145
ENST00000556969
ENST00000557670
ENST00000555036
ENST00000555873 ENSP00000450726
ENST00000555085
ENST00000622441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 31 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019905 syntaxin binding
GO:0032403 protein complex binding
Biological Process
GO:0001822 kidney development
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007030 Golgi organization
GO:0034205 beta-amyloid formation
GO:0035459 cargo loading into vesicle
GO:0035964 COPI-coated vesicle budding
GO:0043279 response to alkaloid
GO:0045055 regulated secretory pathway
GO:0048199 vesicle targeting, to, from or within Golgi
GO:0048205 COPI coating of Golgi vesicle
GO:0048208 COPII vesicle coating
GO:0051259 protein oligomerization
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030137 COPI-coated vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042470 melanosome
GO:0042589 zymogen granule membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
GO:0070765 gamma-secretase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021248
View Gene Order
ENSBTAG00000005694
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593028 Hs.74137
RefSeq NM_006827
HUGO
OMIM
CCDS CCDS9840
HPRD 12013
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca