Homo sapiens Gene: CCND2 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-12912.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CCND2 | ||||||||||||||||||||||
Gene Name | cyclin D2 | ||||||||||||||||||||||
Synonyms | KIAK0002; MPPH3 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000118971 | ||||||||||||||||||||||
Encoded Proteins |
cyclin D2
cyclin D2
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:4273772-4305350 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p13.32 | ||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH |
BCR pathway
|
||||||||||||||||||||||
REACTOME |
Cyclin D associated events in G1 pathway
G1 Phase pathway
Mitotic G1-G1/S phases pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
|
||||||||||||||||||||||
KEGG |
Wnt signaling pathway pathway
Cell cycle pathway
Focal adhesion pathway
Jak-STAT signaling pathway pathway
p53 signaling pathway pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Validated targets of C-MYC transcriptional activation
Regulation of nuclear beta catenin signaling and target gene transcription
IL2 signaling events mediated by STAT5
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P30279 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 894 | ||||||||||||||||||||||
UniGene | Hs.376071 Hs.609915 Hs.706154 Hs.706277 | ||||||||||||||||||||||
RefSeq | NM_001759 | ||||||||||||||||||||||
HUGO | HGNC:1583 | ||||||||||||||||||||||
OMIM | 123833 | ||||||||||||||||||||||
CCDS | CCDS8524 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF518005 AK291146 BC010958 BC089384 BT019847 CH471116 D13639 M88080 M88081 M88082 M88083 M90813 X68452 | ||||||||||||||||||||||
GenPept | AAA51926 AAA51928 AAH10958 AAH89384 AAM54041 AAV38650 BAA02802 BAF83835 CAA48493 EAW88851 | ||||||||||||||||||||||
RNA Seq Atlas | 894 | ||||||||||||||||||||||