Version 5.4
Homo sapiens Gene: STIM2
Summary
InnateDB Gene IDBG-12896.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STIM2
Gene Name stromal interaction molecule 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109689
Encoded Proteins
IDBP-806793
stromal interaction molecule 2
IDBP-806794
stromal interaction molecule 2
IDBP-477047
stromal interaction molecule 2
IDBP-480259
stromal interaction molecule 2
IDBP-474149
stromal interaction molecule 2
IDBP-806828
stromal interaction molecule 2
IDBP-479285
stromal interaction molecule 2
IDBP-479039
stromal interaction molecule 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:26857678-27025381
Strand Forward strand
Band p15.2
Transcripts
ENST00000494628 ENSP00000473527
ENST00000463501 ENSP00000473283
ENST00000478425
ENST00000467087 ENSP00000419073
ENST00000467011 ENSP00000419383
ENST00000465503 ENSP00000417569
ENST00000478049 ENSP00000473581
ENST00000473519 ENSP00000420113
ENST00000477474 ENSP00000419536
ENST00000504511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0032237 activation of store-operated calcium channel activity
GO:0051928 positive regulation of calcium ion transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039156
View Gene Order
ENSBTAG00000019353
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL R4GNC5
UniProt Splice Variant
Entrez Gene 57620
UniGene
RefSeq NM_001169117 NM_001169118 NM_020860
HUGO HGNC:19205
OMIM 610841
CCDS CCDS3440 CCDS54751 CCDS54752
HPRD
IMGT
EMBL AC006928 AC106047
GenPept
RNA Seq Atlas 57620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca