Version 5.4
Homo sapiens Gene: TRIO
Summary
InnateDB Gene IDBG-12835.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIO
Gene Name trio Rho guanine nucleotide exchange factor
Synonyms ARHGEF23; tgat
Species Homo sapiens
Ensembl Gene ENSG00000038382
Encoded Proteins
IDBP-12837
triple functional domain (PTPRF interacting)
IDBP-12841
triple functional domain (PTPRF interacting)
IDBP-604285
triple functional domain (PTPRF interacting)
IDBP-478993
triple functional domain (PTPRF interacting)
IDBP-478908
triple functional domain (PTPRF interacting)
IDBP-809671
trio Rho guanine nucleotide exchange factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:14143702-14532128
Strand Forward strand
Band p15.2
Transcripts
ENST00000344204 ENSP00000339299
ENST00000344135 ENSP00000339291
ENST00000505971
ENST00000502816
ENST00000509967 ENSP00000445592
ENST00000512070 ENSP00000421555
ENST00000513206 ENSP00000426342
ENST00000504606
ENST00000515144
ENST00000510757
ENST00000502490
ENST00000509354
ENST00000512303
ENST00000512979
ENST00000507714
ENST00000515710
ENST00000506611
ENST00000511019
ENST00000510281
ENST00000503399
ENST00000508343
ENST00000508283
ENST00000508717
ENST00000620511 ENSP00000483869
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019899 enzyme binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0009103 lipopolysaccharide biosynthetic process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022263
View Gene Order
ENSBTAG00000005514
Not yet available
Pathways
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_18266
Axon guidance pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
netrin_pathway
Netrin-mediated signaling events
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.130031 Hs.619556 Hs.653527
RefSeq NM_007118 XM_006714495
HUGO
OMIM
CCDS CCDS3883
HPRD 03537
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca