Version 5.4
Homo sapiens Gene: NME8
Summary
InnateDB Gene IDBG-12785.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NME8
Gene Name NME/NM23 family member 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000086288
Encoded Proteins
IDBP-12787
thioredoxin domain containing 3 (spermatozoa)
IDBP-372422
thioredoxin domain containing 3 (spermatozoa)
IDBP-372425
thioredoxin domain containing 3 (spermatozoa)
IDBP-372428
thioredoxin domain containing 3 (spermatozoa)
IDBP-372430
thioredoxin domain containing 3 (spermatozoa)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:37848597-37900401
Strand Forward strand
Band p14.1
Transcripts
ENST00000199447 ENSP00000199447
ENST00000455500 ENSP00000390047
ENST00000444718 ENSP00000390596
ENST00000440017 ENSP00000397063
ENST00000426106 ENSP00000408841
ENST00000476435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041138
View Gene Order
ENSBTAG00000015353
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.723454
RefSeq NM_016616
HUGO
OMIM
CCDS CCDS5452
HPRD 16243
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca