Version 5.4
Homo sapiens Gene: DNAJA3
Summary
InnateDB Gene IDBG-12754.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJA3
Gene Name DnaJ (Hsp40) homolog, subfamily A, member 3
Synonyms HCA57; hTID-1; TID1
Species Homo sapiens
Ensembl Gene ENSG00000103423
Encoded Proteins
IDBP-12756
DnaJ (Hsp40) homolog, subfamily A, member 3
IDBP-12758
DnaJ (Hsp40) homolog, subfamily A, member 3
IDBP-367286
DnaJ (Hsp40) homolog, subfamily A, member 3
IDBP-745459
IDBP-745283
IDBP-750813
IDBP-753300
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4425805-4456775
Strand Forward strand
Band p13.3
Transcripts
ENST00000355296 ENSP00000347445
ENST00000262375 ENSP00000262375
ENST00000431375 ENSP00000393970
ENST00000572974
ENST00000575106 ENSP00000458868
ENST00000573120
ENST00000577083
ENST00000574393
ENST00000570857 ENSP00000460358
ENST00000576911 ENSP00000459098
ENST00000572009
ENST00000574895 ENSP00000459088
ENST00000576180
ENST00000572139
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 71 [view]
Protein-Protein 70 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005133 interferon-gamma receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0030544 Hsp70 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0031072 heat shock protein binding
GO:0046872 metal ion binding
GO:0051059 NF-kappaB binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006264 mitochondrial DNA replication
GO:0006457 protein folding
GO:0006469 negative regulation of protein kinase activity
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006924 activation-induced cell death of T cells
GO:0007005 mitochondrion organization
GO:0007264 small GTPase mediated signal transduction
GO:0007528 neuromuscular junction development
GO:0007569 cell aging
GO:0008285 negative regulation of cell proliferation
GO:0009408 response to heat
GO:0031398 positive regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033077 T cell differentiation in thymus
GO:0034341 response to interferon-gamma
GO:0042102 positive regulation of T cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043069 negative regulation of programmed cell death
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050821 protein stabilization
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005884 actin filament
GO:0008385 IkappaB kinase complex
GO:0019897 extrinsic component of plasma membrane
GO:0030054 cell junction
GO:0031594 neuromuscular junction
GO:0033256 I-kappaB/NF-kappaB complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004069
View Gene Order
ENSBTAG00000010013
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.459779 Hs.692032
RefSeq NM_001135110 NM_001286516 NM_005147
HUGO
OMIM
CCDS CCDS10515 CCDS45400 CCDS66930
HPRD 09758
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca