Version 5.4
Homo sapiens Gene: CCKAR
Summary
InnateDB Gene IDBG-12723.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCKAR
Gene Name cholecystokinin A receptor
Synonyms CCK-A; CCK1-R; CCK1R; CCKRA
Species Homo sapiens
Ensembl Gene ENSG00000163394
Encoded Proteins
IDBP-12725
cholecystokinin A receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:26481400-26490462
Strand Reverse strand
Band p15.2
Transcripts
ENST00000295589 ENSP00000295589
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004951 cholecystokinin receptor activity
Biological Process
GO:0001764 neuron migration
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007409 axonogenesis
GO:0007584 response to nutrient
GO:0007586 digestion
GO:0007631 feeding behavior
GO:0030900 forebrain development
GO:0038188 cholecystokinin signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029193
View Gene Order
ENSBTAG00000004988
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
hsa04972
Pancreatic secretion pathway
INOH
PID NCI
Cross-References
SwissProt P32238
TrEMBL
UniProt Splice Variant
Entrez Gene 886
UniGene Hs.129
RefSeq NM_000730
HUGO HGNC:1570
OMIM 118444
CCDS CCDS3438
HPRD
IMGT
EMBL AK313978 AY322549 BC074987 CH471069 D85606 L13605 L19315 U23427 U23428 U23429 U23430
GenPept AAA02819 AAA35659 AAA91123 AAH74987 AAP84362 BAA90879 BAG36692 EAW92850
RNA Seq Atlas 886

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca