Version 5.4
Homo sapiens Gene: HCN2
Summary
InnateDB Gene IDBG-12524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCN2
Gene Name hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Synonyms BCNG-2; BCNG2; HAC-1
Species Homo sapiens
Ensembl Gene ENSG00000099822
Encoded Proteins
IDBP-12526
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:589893-617159
Strand Forward strand
Band p13.3
Transcripts
ENST00000251287 ENSP00000251287
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005222 intracellular cAMP activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0030552 cAMP binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 ion transport
GO:0007267 cell-cell signaling
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020331
View Gene Order
ENSBTAG00000015050
Not yet available
Pathways
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_75862
HCN channels pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UL51
TrEMBL Q09ND3
UniProt Splice Variant
Entrez Gene 610
UniGene Hs.124161
RefSeq NM_001194
HUGO HGNC:4846
OMIM 602781
CCDS CCDS12035
HPRD
IMGT
EMBL AC004449 AC005559 AF064877 AF065164 AJ012582 AJ133727 AJ133728 AJ133729 AJ133730 AJ133731 AJ133732 AJ133733 AJ133734 DQ854815
GenPept AAC28444 AAC33280 AAC39760 ABI75145 CAB42602 CAB42630
RNA Seq Atlas 610

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca