Version 5.4
Homo sapiens Gene: LEO1
Summary
InnateDB Gene IDBG-12296.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEO1
Gene Name Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166477
Encoded Proteins
IDBP-12298
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
IDBP-12300
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:51938025-51971806
Strand Reverse strand
Band q21.2
Transcripts
ENST00000299601 ENSP00000299601
ENST00000315141 ENSP00000314610
ENST00000558949
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 42 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001711 endodermal cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0006378 mRNA polyadenylation
GO:0010390 histone monoubiquitination
GO:0016055 Wnt signaling pathway
GO:0019827 stem cell maintenance
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0016593 Cdc73/Paf1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042487
View Gene Order
ENSBTAG00000013830
Not yet available
Pathways
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567662
RefSeq NM_001286430 NM_138792
HUGO
OMIM
CCDS CCDS10146 CCDS66767
HPRD 11231
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca