Version 5.4
Homo sapiens Gene: SEMA5A
Summary
InnateDB Gene IDBG-12173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA5A
Gene Name sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Synonyms SEMAF; semF
Species Homo sapiens
Ensembl Gene ENSG00000112902
Encoded Proteins
IDBP-12175
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
IDBP-476584
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
IDBP-483625
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
IDBP-483473
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:9035026-9546075
Strand Reverse strand
Band p15.31
Transcripts
ENST00000382496 ENSP00000371936
ENST00000513968 ENSP00000421961
ENST00000514923 ENSP00000424171
ENST00000509486 ENSP00000423574
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008046 axon guidance receptor activity
GO:0030215 semaphorin receptor binding
GO:0035373 chondroitin sulfate proteoglycan binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0045545 syndecan binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0021536 diencephalon development
GO:0030836 positive regulation of actin filament depolymerization
GO:0035413 positive regulation of catenin import into nucleus
GO:0045766 positive regulation of angiogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0050918 positive chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:1990256 signal clustering
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2001028 positive regulation of endothelial cell chemotaxis
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022231
View Gene Order
ENSBTAG00000005021
Not yet available
Pathways
NETPATH
REACTOME
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_22161
Post-translational protein modification pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.27621 Hs.603024 Hs.700222
RefSeq NM_003966 XM_006714506 XM_006714507 XM_006714508
HUGO
OMIM
CCDS CCDS3875
HPRD 10219
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca