InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLX4

Summary

InnateDB Gene

IDBG-12161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLX4

Gene Name

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000188827

Encoded Proteins

IDBP-12163

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24412650

HIV auxiliary protein Vpr directly activates SLX4 to promote cell cycle arrest at the G2/M, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex, to escape from innate immune sensing.

Entrez Gene

Summary

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:3581181-3611598

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000294008	ENSP00000294008
ENST00000466154
ENST00000486524

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008821	crossover junction endodeoxyribonuclease activity
GO:0017108	5'-flap endonuclease activity
GO:0048257	3'-flap endonuclease activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing
GO:0043085	positive regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0072429	response to intra-S DNA damage checkpoint signaling

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030054	cell junction
GO:0033557	Slx1-Slx4 complex
GO:0048476	Holliday junction resolvase complex
GO:0070522	ERCC4-ERCC1 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039738

View Gene Order

ENSBTAG00000004509

Not yet available

Cross-References

SwissProt

Q8IY92

TrEMBL

UniProt Splice Variant

Entrez Gene

84464

UniGene

Hs.143681

RefSeq

NM_032444

HUGO

HGNC:23845

OMIM

613278

CCDS

CCDS10506

HPRD

IMGT

EMBL

AB058687 AB075867 AC006111 AL442083

GenPept

BAB47413 BAB85573 CAH10659

RNA Seq Atlas

84464