InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADAMTS1

Summary

InnateDB Gene

IDBG-1192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS1

Gene Name

ADAM metallopeptidase with thrombospondin type 1 motif, 1

Synonyms

C3-C5; METH1

Species

Homo sapiens

Ensembl Gene

ENSG00000154734

Encoded Proteins

IDBP-1194

ADAM metallopeptidase with thrombospondin type 1 motif, 1

IDBP-361197

ADAM metallopeptidase with thrombospondin type 1 motif, 1

IDBP-485423

ADAM metallopeptidase with thrombospondin type 1 motif, 1

IDBP-473729

ADAM metallopeptidase with thrombospondin type 1 motif, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:26835747-26845409

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000284984	ENSP00000284984
ENST00000451462	ENSP00000403404
ENST00000464589
ENST00000492656
ENST00000517777	ENSP00000429557
ENST00000517452	ENSP00000431065

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001542	ovulation from ovarian follicle
GO:0001822	kidney development
GO:0006508	proteolysis
GO:0007229	integrin-mediated signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0060347	heart trabecula formation

Cellular Component

GO:0005604	basement membrane
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0031410	cytoplasmic vesicle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022893

View Gene Order

ENSBTAG00000000706

Not yet available

Pathways

NETPATH

REACTOME

REACT_22161

Post-translational protein modification pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_200727

O-linked glycosylation pathway

REACT_17015

Metabolism of proteins pathway

REACT_200626

O-glycosylation of TSR domain-containing proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.643357

RefSeq

NM_006988

HUGO

OMIM

CCDS

CCDS33524

HPRD

05530

IMGT

EMBL

GenPept

RNA Seq Atlas