Version 5.4
Homo sapiens Gene: ERC1
Summary
InnateDB Gene IDBG-11681.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERC1
Gene Name ELKS/RAB6-interacting/CAST family member 1
Synonyms Cast2; ELKS; ERC-1; RAB6IP2
Species Homo sapiens
Ensembl Gene ENSG00000082805
Encoded Proteins
IDBP-11683
ELKS/RAB6-interacting/CAST family member 1
IDBP-11687
ELKS/RAB6-interacting/CAST family member 1
IDBP-11689
ELKS/RAB6-interacting/CAST family member 1
IDBP-235821
ELKS/RAB6-interacting/CAST family member 1
IDBP-360960
ELKS/RAB6-interacting/CAST family member 1
IDBP-717093
IDBP-583189
ELKS/RAB6-interacting/CAST family member 1
IDBP-601117
ELKS/RAB6-interacting/CAST family member 1
IDBP-596640
ELKS/RAB6-interacting/CAST family member 1
IDBP-598300
ELKS/RAB6-interacting/CAST family member 1
IDBP-718090
IDBP-717470
IDBP-718446
IDBP-717168
IDBP-718009
IDBP-807439
ELKS/RAB6-interacting/CAST family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:990509-1495933
Strand Forward strand
Band p13.33
Transcripts
ENST00000360905 ENSP00000354158
ENST00000355446 ENSP00000347621
ENST00000347735 ENSP00000340054
ENST00000397203 ENSP00000380386
ENST00000440394 ENSP00000410064
ENST00000515210
ENST00000545318 ENSP00000465628
ENST00000543086 ENSP00000438546
ENST00000542302 ENSP00000445336
ENST00000545948 ENSP00000442976
ENST00000546231 ENSP00000442739
ENST00000539007
ENST00000536573
ENST00000541503
ENST00000544277
ENST00000543263
ENST00000539802 ENSP00000467196
ENST00000543151
ENST00000538971
ENST00000587595
ENST00000588412 ENSP00000467339
ENST00000592048 ENSP00000467476
ENST00000589028 ENSP00000468263
ENST00000589132 ENSP00000464959
ENST00000611180 ENSP00000479523
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0043522 leucine zipper domain binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007252 I-kappaB phosphorylation
GO:0007275 multicellular organismal development
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0008385 IkappaB kinase complex
GO:0042734 presynaptic membrane
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030172
View Gene Order
ENSBTAG00000013658
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
il1pathway
IL1-mediated signaling events
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 23085
UniGene Hs.601216 Hs.704234
RefSeq NM_178039 NM_178040
HUGO HGNC:17072
OMIM 607127
CCDS CCDS53732 CCDS8508
HPRD 06181
IMGT
EMBL
GenPept
RNA Seq Atlas 23085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca