Homo sapiens Gene: TNFRSF10D
Summary
InnateDB Gene IDBG-11632.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF10D
Gene Name tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Synonyms CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD
Species Homo sapiens
Ensembl Gene ENSG00000173530
Encoded Proteins
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:23135588-23164030
Strand Reverse strand
Band p21.3
Transcripts
ENST00000312584 ENSP00000310263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0045569 TRAIL binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Apoptosis pathway
Cytokine-cytokine receptor interaction pathway
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
TRAIL signaling pathway
Direct p53 effectors
Cross-References
SwissProt Q9UBN6
TrEMBL
UniProt Splice Variant
Entrez Gene 8793
UniGene Hs.213467
RefSeq NM_003840
HUGO HGNC:11907
OMIM 603614
CCDS CCDS6038
HPRD
IMGT
EMBL AF021232 AF021233 AF023849 AF029761 AK313528 AY358285 BC052270
GenPept AAC32765 AAC32766 AAC52053 AAD03477 AAH52270 AAQ88652 BAG36307
RNA Seq Atlas 8793