Version 5.4
Homo sapiens Gene: WNK1
Summary
InnateDB Gene IDBG-11521.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNK1
Gene Name WNK lysine deficient protein kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000060237
Encoded Proteins
IDBP-11523
WNK lysine deficient protein kinase 1
IDBP-11527
WNK lysine deficient protein kinase 1
IDBP-360877
WNK lysine deficient protein kinase 1
IDBP-595981
WNK lysine deficient protein kinase 1
IDBP-584464
WNK lysine deficient protein kinase 1
IDBP-600993
WNK lysine deficient protein kinase 1
IDBP-583373
WNK lysine deficient protein kinase 1
IDBP-584921
WNK lysine deficient protein kinase 1
IDBP-603749
WNK lysine deficient protein kinase 1
IDBP-587013
WNK lysine deficient protein kinase 1
IDBP-590129
WNK lysine deficient protein kinase 1
IDBP-601763
WNK lysine deficient protein kinase 1
IDBP-717909
IDBP-718110
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:752593-911452
Strand Forward strand
Band p13.33
Transcripts
ENST00000315939 ENSP00000313059
ENST00000340908 ENSP00000341292
ENST00000447667 ENSP00000392542
ENST00000535572 ENSP00000441972
ENST00000540360
ENST00000538787
ENST00000544965 ENSP00000438313
ENST00000545285 ENSP00000446462
ENST00000535698 ENSP00000439552
ENST00000542543
ENST00000545055
ENST00000534872 ENSP00000446253
ENST00000542424
ENST00000537603
ENST00000544559 ENSP00000437503
ENST00000543065 ENSP00000438985
ENST00000540885
ENST00000537687 ENSP00000444465
ENST00000530271 ENSP00000433548
ENST00000574564 ENSP00000460651
ENST00000574679 ENSP00000459380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
Experimentally validated
Total 53 [view]
Protein-Protein 51 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019869 chloride channel inhibitor activity
GO:0019902 phosphatase binding
Biological Process
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006811 ion transport
GO:0010923 negative regulation of phosphatase activity
GO:0018107 peptidyl-threonine phosphorylation
GO:0035556 intracellular signal transduction
GO:0048666 neuron development
GO:0050794 regulation of cellular process
GO:0090188 negative regulation of pancreatic juice secretion
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045962
View Gene Order
ENSBTAG00000005221
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9H4A3
TrEMBL A5XEH8 F5GWT4 F6UYG0 H0YFK5 H0YFP5 H0YH68 I3L251
UniProt Splice Variant
Entrez Gene 65125
UniGene Hs.743285
RefSeq NM_001184985 NM_014823 NM_018979 NM_213655 XM_006719003
HUGO HGNC:14540
OMIM 605232
CCDS CCDS53731 CCDS73419 CCDS8506
HPRD
IMGT
EMBL AB002342 AC004765 AC004803 AF061944 AJ296290 AY231477 BC013629 BC130467 BC130469 BK004108 DQ925671 FJ515833 JQ358908
GenPept AAF31483 AAH13629 AAI30468 AAI30470 AAO46160 ABL59898 ACS13726 ACS13727 ACS13728 AEY99342 BAA20802 CAC15059 DAA04494
RNA Seq Atlas 65125

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca