InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KDM5A

Summary

InnateDB Gene

IDBG-11318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM5A

Gene Name

lysine (K)-specific demethylase 5A

Synonyms

RBBP-2; RBBP2; RBP2

Species

Homo sapiens

Ensembl Gene

ENSG00000073614

Encoded Proteins

IDBP-11320

lysine (K)-specific demethylase 5A

IDBP-229708

lysine (K)-specific demethylase 5A

IDBP-584756

lysine (K)-specific demethylase 5A

IDBP-597633

lysine (K)-specific demethylase 5A

IDBP-600251

lysine (K)-specific demethylase 5A

IDBP-599910

lysine (K)-specific demethylase 5A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. [provided by RefSeq, Mar 2010]
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:280129-389454

Strand

Reverse strand

Band

p13.33

Transcripts

ENST00000382815	ENSP00000372265
ENST00000399788	ENSP00000382688
ENST00000540838
ENST00000540156
ENST00000544760	ENSP00000440622
ENST00000535269
ENST00000541335
ENST00000540168
ENST00000544777
ENST00000535014	ENSP00000443854
ENST00000536014	ENSP00000438203
ENST00000543507	ENSP00000444251

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	28 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0016568	chromatin modification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030180

View Gene Order

ENSBTAG00000020472

Not yet available

Pathways

NETPATH

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.618774 Hs.76272

RefSeq

NM_001042603

HUGO

OMIM

CCDS

CCDS41736

HPRD

08915

IMGT

EMBL

GenPept

RNA Seq Atlas