Version 5.4
Homo sapiens Gene: PDLIM2
Summary
InnateDB Gene IDBG-11055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDLIM2
Gene Name PDZ and LIM domain 2 (mystique)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120913
Encoded Proteins
IDBP-11057
PDZ and LIM domain 2 (mystique)
IDBP-11059
PDZ and LIM domain 2 (mystique)
IDBP-11061
PDZ and LIM domain 2 (mystique)
IDBP-234634
PDZ and LIM domain 2 (mystique)
IDBP-234636
PDZ and LIM domain 2 (mystique)
IDBP-295045
PDZ and LIM domain 2 (mystique)
IDBP-295047
PDZ and LIM domain 2 (mystique)
IDBP-363255
PDZ and LIM domain 2 (mystique)
IDBP-363293
PDZ and LIM domain 2 (mystique)
IDBP-363301
PDZ and LIM domain 2 (mystique)
IDBP-363303
PDZ and LIM domain 2 (mystique)
IDBP-363304
PDZ and LIM domain 2 (mystique)
IDBP-810038
PDZ and LIM domain 2 (mystique)
IDBP-363323
PDZ and LIM domain 2 (mystique)
IDBP-810031
PDZ and LIM domain 2 (mystique)
IDBP-810034
PDZ and LIM domain 2 (mystique)
IDBP-810025
PDZ and LIM domain 2 (mystique)
IDBP-810035
PDZ and LIM domain 2 (mystique)
IDBP-810042
PDZ and LIM domain 2 (mystique)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22578279-22598025
Strand Forward strand
Band p21.3
Transcripts
ENST00000308354 ENSP00000312634
ENST00000265810 ENSP00000265810
ENST00000339162 ENSP00000342035
ENST00000397761 ENSP00000380868
ENST00000397760 ENSP00000380867
ENST00000409417 ENSP00000387084
ENST00000409141 ENSP00000386868
ENST00000456545 ENSP00000401992
ENST00000452226 ENSP00000394376
ENST00000436754 ENSP00000397738
ENST00000426493 ENSP00000392920
ENST00000429812 ENSP00000407643
ENST00000443561 ENSP00000478826
ENST00000416159 ENSP00000412936
ENST00000448520 ENSP00000481074
ENST00000491330
ENST00000464275 ENSP00000481268
ENST00000616289 ENSP00000478370
ENST00000622226
ENST00000614502 ENSP00000477546
ENST00000622702 ENSP00000479453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031005 filamin binding
GO:0032036 myosin heavy chain binding
GO:0051371 muscle alpha-actinin binding
GO:0051393 alpha-actinin binding
Biological Process
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022090
View Gene Order
ENSBTAG00000007369
Not yet available
Cross-References
SwissProt Q96JY6
TrEMBL B3KPU0 C9J0X3 C9J760 C9JS55 C9JSR2 C9K0F0
UniProt Splice Variant
Entrez Gene 64236
UniGene Hs.632034
RefSeq NM_021630 NM_176871 NM_198042
HUGO HGNC:13992
OMIM 609722
CCDS CCDS34860 CCDS34861 CCDS6032
HPRD 17831
IMGT
EMBL AC037459 AF289563 AK024498 AK027800 AK056748 AY007729 AY070438 AY217349 BC021556 BC071774 CH471080
GenPept AAG16633 AAH21556 AAH71774 AAL55747 AAL65265 AAO45102 BAB15788 BAB55378 BAG51802 EAW63667 EAW63669
RNA Seq Atlas 102725251 64236

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca