Version 5.4
Homo sapiens Gene: PPP3CC
Summary
InnateDB Gene IDBG-10931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP3CC
Gene Name protein phosphatase 3, catalytic subunit, gamma isozyme
Synonyms CALNA3; CNA3; PP2Bgamma
Species Homo sapiens
Ensembl Gene ENSG00000120910
Encoded Proteins
IDBP-10933
protein phosphatase 3, catalytic subunit, gamma isozyme
IDBP-10935
protein phosphatase 3, catalytic subunit, gamma isozyme
IDBP-234601
protein phosphatase 3, catalytic subunit, gamma isozyme
IDBP-481880
protein phosphatase 3, catalytic subunit, gamma isozyme
IDBP-474216
protein phosphatase 3, catalytic subunit, gamma isozyme
IDBP-476835
protein phosphatase 3, catalytic subunit, gamma isozyme
IDBP-477873
protein phosphatase 3, catalytic subunit, gamma isozyme
IDBP-475702
protein phosphatase 3, catalytic subunit, gamma isozyme
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:22440819-22541142
Strand Forward strand
Band p21.3
Transcripts
ENST00000240139 ENSP00000240139
ENST00000289963 ENSP00000289963
ENST00000397775 ENSP00000380878
ENST00000518852 ENSP00000429379
ENST00000522000 ENSP00000428358
ENST00000522034 ENSP00000430783
ENST00000521651 ENSP00000428390
ENST00000523620 ENSP00000430555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005516 calmodulin binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0008152 metabolic process
GO:0016311 dephosphorylation
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022092
View Gene Order
ENSBTAG00000020133
Not yet available
Pathways
NETPATH
REACTOME
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_14797
Signaling by GPCR pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04020
Calcium signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04114
Oocyte meiosis pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt
TrEMBL E5RJH4
UniProt Splice Variant
Entrez Gene 5533
UniGene Hs.731683
RefSeq NM_001243974 NM_001243975 NM_005605
HUGO HGNC:9316
OMIM 114107
CCDS CCDS34859 CCDS59093 CCDS59094
HPRD 00236
IMGT
EMBL AC037459 AC087854
GenPept
RNA Seq Atlas 5533

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca