Version 5.4
Homo sapiens Gene: CHN2
Summary
InnateDB Gene IDBG-10872.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHN2
Gene Name chimerin 2
Synonyms ARHGAP3; BCH; CHN2-3; RHOGAP3
Species Homo sapiens
Ensembl Gene ENSG00000106069
Encoded Proteins
IDBP-10874
chimerin (chimaerin) 2
IDBP-294578
chimerin (chimaerin) 2
IDBP-294575
chimerin (chimaerin) 2
IDBP-369976
chimerin (chimaerin) 2
IDBP-370034
chimerin (chimaerin) 2
IDBP-370037
chimerin (chimaerin) 2
IDBP-370043
chimerin (chimaerin) 2
IDBP-370049
chimerin (chimaerin) 2
IDBP-370052
chimerin (chimaerin) 2
IDBP-370056
chimerin (chimaerin) 2
IDBP-718558
IDBP-585364
chimerin (chimaerin) 2
IDBP-586936
chimerin (chimaerin) 2
IDBP-598554
chimerin (chimaerin) 2
IDBP-596158
chimerin (chimaerin) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:29122274-29514328
Strand Forward strand
Band p14.3
Transcripts
ENST00000222792 ENSP00000222792
ENST00000409350 ENSP00000386968
ENST00000409964
ENST00000409922
ENST00000409041 ENSP00000386849
ENST00000410098
ENST00000439384 ENSP00000409843
ENST00000412536
ENST00000446446 ENSP00000396867
ENST00000424025 ENSP00000406337
ENST00000435288 ENSP00000400282
ENST00000439711 ENSP00000387425
ENST00000421775 ENSP00000394284
ENST00000412711
ENST00000433720 ENSP00000398326
ENST00000443025
ENST00000423511 ENSP00000462650
ENST00000461824
ENST00000474070 ENSP00000441183
ENST00000470261
ENST00000495789 ENSP00000438587
ENST00000482820
ENST00000478128
ENST00000483081
ENST00000491856
ENST00000467441
ENST00000493906
ENST00000539406 ENSP00000444063
ENST00000539389 ENSP00000440526
ENST00000588769
ENST00000582692
ENST00000578605
ENST00000606897
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0009967 positive regulation of signal transduction
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004633
View Gene Order
ENSBTAG00000020931
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
erbb1_downstream_pathway
ErbB1 downstream signaling
Cross-References
SwissProt P52757
TrEMBL
UniProt Splice Variant
Entrez Gene 644086
UniGene Hs.653033 Hs.666750 Hs.734596
RefSeq NM_001039936 NM_001293072 NM_001293077 NM_001293078 NM_001293081 NM_004067
HUGO HGNC:1944
OMIM 602857
CCDS CCDS5420
HPRD 04173
IMGT
EMBL AC004417 AC004593 AC005232 AC007096 AC007255 AK026415 AK313021 AK316030 BC112155 CH236948 CH471073 EU732752 EU732753 EU732754 EU732758 EU732762 GQ924106 L29126 U07223 U28926
GenPept AAA16836 AAA19191 AAA86528 AAC06177 AAI12156 AAS07498 ACF04989 ACF04990 ACF04991 ACF04995 ACF04999 ADK47390 BAG35856 BAH14401 EAL24205 EAW93919
RNA Seq Atlas 101928168 1124 644086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca