Version 5.4
Homo sapiens Gene: MAP3K9
Summary
InnateDB Gene IDBG-10857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP3K9
Gene Name mitogen-activated protein kinase kinase kinase 9
Synonyms MEKK9; MLK1; PRKE1
Species Homo sapiens
Ensembl Gene ENSG00000006432
Encoded Proteins
IDBP-10861
mitogen-activated protein kinase kinase kinase 9
IDBP-587518
mitogen-activated protein kinase kinase kinase 9
IDBP-594773
mitogen-activated protein kinase kinase kinase 9
IDBP-596987
mitogen-activated protein kinase kinase kinase 9
IDBP-596946
mitogen-activated protein kinase kinase kinase 9
IDBP-809898
mitogen-activated protein kinase kinase kinase 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70722526-70809534
Strand Reverse strand
Band q24.2
Transcripts
ENST00000381250 ENSP00000370649
ENST00000554752 ENSP00000451612
ENST00000555993 ENSP00000451263
ENST00000553414 ENSP00000451038
ENST00000554146 ENSP00000451921
ENST00000554024
ENST00000611979 ENSP00000480011
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007256 activation of JNKK activity
GO:0007257 activation of JUN kinase activity
GO:0008219 cell death
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042724
View Gene Order
ENSBTAG00000005700
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445496 Hs.593542 Hs.630318 Hs.641566
RefSeq NM_001284230 NM_001284231 NM_001284232 NM_033141
HUGO
OMIM
CCDS CCDS32112 CCDS61485 CCDS61488 CCDS73650
HPRD 15965
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca