Version 5.4
Homo sapiens Gene: FGFBP1
Summary
InnateDB Gene IDBG-10715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGFBP1
Gene Name fibroblast growth factor binding protein 1
Synonyms FGF-BP; FGF-BP1; FGFBP; FGFBP-1; HBP17
Species Homo sapiens
Ensembl Gene ENSG00000137440
Encoded Proteins
IDBP-10717
fibroblast growth factor binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:15935569-15938740
Strand Reverse strand
Band p15.32
Transcripts
ENST00000382333 ENSP00000371770
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048373
View Gene Order
ENSBTAG00000031497
Not yet available
Cross-References
SwissProt Q14512
TrEMBL
UniProt Splice Variant
Entrez Gene 9982
UniGene Hs.1690 Hs.734516
RefSeq NM_005130
HUGO HGNC:19695
OMIM 607737
CCDS CCDS3418
HPRD
IMGT
EMBL AF149412 AK291307 BC003628 BC008910 CH471069 M60047
GenPept AAA58636 AAD39216 AAH03628 AAH08910 BAF83996 EAW92748
RNA Seq Atlas 9982

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca