Version 5.4
Homo sapiens Gene: CD38
Summary
InnateDB Gene IDBG-10668.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD38
Gene Name CD38 molecule
Synonyms ADPRC 1; T10
Species Homo sapiens
Ensembl Gene ENSG00000004468
Encoded Proteins
IDBP-10672
CD38 molecule
IDBP-476344
CD38 molecule
IDBP-476460
CD38 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:15778275-15853230
Strand Forward strand
Band p15.32
Transcripts
ENST00000226279 ENSP00000226279
ENST00000502843 ENSP00000427277
ENST00000506191
ENST00000511430
ENST00000510674 ENSP00000423047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003953 NAD+ nucleosidase activity
GO:0016740 transferase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016849 phosphorus-oxygen lyase activity
GO:0050135 NAD(P)+ nucleosidase activity
Biological Process
GO:0001666 response to hypoxia
GO:0007165 signal transduction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007565 female pregnancy
GO:0008152 metabolic process
GO:0009725 response to hormone
GO:0030307 positive regulation of cell growth
GO:0030890 positive regulation of B cell proliferation
GO:0032024 positive regulation of insulin secretion
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032570 response to progesterone
GO:0033194 response to hydroperoxide
GO:0034097 response to cytokine
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0045779 negative regulation of bone resorption
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045907 positive regulation of vasoconstriction
GO:0050853 B cell receptor signaling pathway
GO:0060292 long term synaptic depression
GO:0070555 response to interleukin-1
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029084
View Gene Order
ENSBTAG00000013569
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa00760
Nicotinate and nicotinamide metabolism pathway
hsa04020
Calcium signaling pathway pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
INOH
INOH website
Nicotinate Nicotinamide metabolism pathway
PID NCI
Cross-References
SwissProt P28907
TrEMBL B4DMR7 Q4FCX6
UniProt Splice Variant
Entrez Gene 952
UniGene Hs.735022
RefSeq NM_001775
HUGO HGNC:1667
OMIM 107270
CCDS CCDS3417
HPRD 00116
IMGT
EMBL AK297592 BC007964 D84276 D84277 D84284 DQ091293 M34461
GenPept AAA68482 AAH07964 AAY99634 BAA18964 BAA18965 BAA18966 BAG59979
RNA Seq Atlas 952

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca