Version 5.4
Homo sapiens Gene: SLC10A1
Summary
InnateDB Gene IDBG-10519.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC10A1
Gene Name solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Synonyms NTCP
Species Homo sapiens
Ensembl Gene ENSG00000100652
Encoded Proteins
IDBP-10521
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:69775417-69797289
Strand Reverse strand
Band q24.1
Transcripts
ENST00000216540 ENSP00000216540
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008508 bile acid:sodium symporter activity
GO:0015125 bile acid transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0008206 bile acid metabolic process
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021135
View Gene Order
ENSBTAG00000001881
Not yet available
Pathways
NETPATH
REACTOME
REACT_11042
Recycling of bile acids and salts pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt Q14973
TrEMBL Q9UK36
UniProt Splice Variant
Entrez Gene 6554
UniGene Hs.952
RefSeq NM_003049
HUGO HGNC:10905
OMIM 182396
CCDS CCDS9797
HPRD
IMGT
EMBL AF184235 AY544127 BC069799 BC069822 BC074724 BC126298 BC136355 CH471061 L21893
GenPept AAA36381 AAD56541 AAH69799 AAH69822 AAH74724 AAI26299 AAI36356 AAT11158 EAW81011
RNA Seq Atlas 6554

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca