Version 5.4
Homo sapiens Gene: SKAP2
Summary
InnateDB Gene IDBG-10241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKAP2
Gene Name src kinase associated phosphoprotein 2
Synonyms PRAP; RA70; SAPS; SCAP2; SKAP-HOM; SKAP55R
Species Homo sapiens
Ensembl Gene ENSG00000005020
Encoded Proteins
IDBP-10243
src kinase associated phosphoprotein 2
IDBP-369128
src kinase associated phosphoprotein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:26667062-26995239
Strand Reverse strand
Band p15.2
Transcripts
ENST00000345317 ENSP00000005587
ENST00000432747 ENSP00000408163
ENST00000489977
ENST00000468712
ENST00000495802
ENST00000490456
ENST00000497511
ENST00000481204
ENST00000487720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0006461 protein complex assembly
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0009967 positive regulation of signal transduction
GO:0042113 B cell activation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059182
View Gene Order
ENSBTAG00000005650
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_24
TSLP pathway
REACTOME
REACT_23916
Signal regulatory protein (SIRP) family interactions pathway
REACT_111155
Cell-Cell communication pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.200770 Hs.707840
RefSeq NM_003930 XM_005249901
HUGO
OMIM
CCDS CCDS5400
HPRD 05558
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca