Version 5.4
Homo sapiens Gene: AHRR
Summary
InnateDB Gene IDBG-10192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AHRR
Gene Name aryl-hydrocarbon receptor repressor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000063438
Encoded Proteins
IDBP-10198
aryl-hydrocarbon receptor repressor
IDBP-479807
aryl-hydrocarbon receptor repressor
IDBP-485467
aryl-hydrocarbon receptor repressor
IDBP-478526
aryl-hydrocarbon receptor repressor
IDBP-475985
aryl-hydrocarbon receptor repressor
IDBP-474834
aryl-hydrocarbon receptor repressor
IDBP-484835
aryl-hydrocarbon receptor repressor
IDBP-482181
aryl-hydrocarbon receptor repressor
IDBP-482474
aryl-hydrocarbon receptor repressor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:304176-438291
Strand Forward strand
Band p15.33
Transcripts
ENST00000316418 ENSP00000323816
ENST00000505113 ENSP00000424601
ENST00000512529 ENSP00000424880
ENST00000514523 ENSP00000430914
ENST00000510400 ENSP00000428893
ENST00000515206 ENSP00000430842
ENST00000504625 ENSP00000429944
ENST00000506456 ENSP00000426932
ENST00000510910
ENST00000511487 ENSP00000426076
ENST00000507048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004871 signal transducer activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0033235 positive regulation of protein sumoylation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021575
View Gene Order
ENSBTAG00000026527
Not yet available
Cross-References
SwissProt
TrEMBL D6RE68 D6RF73
UniProt Splice Variant
Entrez Gene 57491
UniGene
RefSeq NM_001242412 NM_020731
HUGO HGNC:346
OMIM 606517
CCDS CCDS43297 CCDS56355
HPRD 07356
IMGT
EMBL AC010442 AC118458
GenPept
RNA Seq Atlas 57491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca