InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BCL2L13

Summary

InnateDB Gene

IDBG-1018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L13

Gene Name

BCL2-like 13 (apoptosis facilitator)

Synonyms

BCL-RAMBO; Bcl2-L-13; MIL1

Species

Homo sapiens

Ensembl Gene

ENSG00000099968

Encoded Proteins

IDBP-1020

BCL2-like 13 (apoptosis facilitator)

IDBP-1022

BCL2-like 13 (apoptosis facilitator)

IDBP-1024

BCL2-like 13 (apoptosis facilitator)

IDBP-229773

BCL2-like 13 (apoptosis facilitator)

IDBP-229777

BCL2-like 13 (apoptosis facilitator)

IDBP-361052

BCL2-like 13 (apoptosis facilitator)

IDBP-586432

BCL2-like 13 (apoptosis facilitator)

IDBP-586796

BCL2-like 13 (apoptosis facilitator)

IDBP-594783

BCL2-like 13 (apoptosis facilitator)

IDBP-592440

BCL2-like 13 (apoptosis facilitator)

IDBP-808608

BCL2-like 13 (apoptosis facilitator)

IDBP-808610

BCL2-like 13 (apoptosis facilitator)

IDBP-808612

BCL2-like 13 (apoptosis facilitator)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:17628855-17730855

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000317582	ENSP00000318883
ENST00000355028	ENSP00000347133
ENST00000337612	ENSP00000338932
ENST00000399782	ENSP00000382682
ENST00000399781
ENST00000399777	ENSP00000382677
ENST00000418951	ENSP00000410019
ENST00000498133	ENSP00000436321
ENST00000464649
ENST00000493680	ENSP00000434764
ENST00000479296
ENST00000485631
ENST00000538149	ENSP00000441344
ENST00000543133	ENSP00000437667
ENST00000611738	ENSP00000477967
ENST00000616863	ENSP00000480014
ENST00000618481	ENSP00000480836

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0042981	regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000009112

View Gene Order

ENSBTAG00000013956

Not yet available

Cross-References

SwissProt

Q9BXK5

TrEMBL

UniProt Splice Variant

Entrez Gene

23786

UniGene

Hs.604999 Hs.627270 Hs.743849

RefSeq

NM_001270732 NM_001270733 NM_001270726 NM_001270727 NM_001270728 NM_001270729 NM_001270730 NM_001270731 NM_001270734 NM_001270735 NM_015367 XM_006724075

HUGO

HGNC:17164

OMIM

CCDS

CCDS74812 CCDS13746 CCDS59447 CCDS59448 CCDS74810 CCDS74811 CCDS74813 CCDS74814

HPRD

09822

IMGT

EMBL

AC006285 AF146568 AF183411 AF246665 AF325209 AK056248 AL133029 BC007658 BC016037 CR456521

GenPept

AAF03602 AAG09680 AAH07658 AAH16037 AAK15150 AAK27358 BAG51659 CAB61361 CAG30407

RNA Seq Atlas

23786