Version 5.4
Homo sapiens Gene: ZFYVE26
Summary
InnateDB Gene IDBG-10059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFYVE26
Gene Name zinc finger, FYVE domain containing 26
Synonyms FYVE-CENT; SPG15
Species Homo sapiens
Ensembl Gene ENSG00000072121
Encoded Proteins
IDBP-10061
zinc finger, FYVE domain containing 26
IDBP-595798
zinc finger, FYVE domain containing 26
IDBP-594574
zinc finger, FYVE domain containing 26
IDBP-595823
zinc finger, FYVE domain containing 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:67727374-67816590
Strand Reverse strand
Band q24.1
Transcripts
ENST00000347230 ENSP00000251119
ENST00000394455
ENST00000554557 ENSP00000450431
ENST00000554523
ENST00000557306 ENSP00000452142
ENST00000554783
ENST00000555452 ENSP00000450603
ENST00000557204
ENST00000557366
ENST00000557407
ENST00000553399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000910 cytokinesis
GO:0008219 cell death
Cellular Component
GO:0005765 lysosomal membrane
GO:0005813 centrosome
GO:0030496 midbody
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066440
View Gene Order
ENSBTAG00000014334
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.630977 Hs.98041
RefSeq NM_015346
HUGO
OMIM
CCDS CCDS9788
HPRD 15734
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca