InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SRY

Summary

InnateDB Gene

IDBG-1.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRY

Gene Name

sex determining region Y

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000184895

Encoded Proteins

IDBP-3

sex determining region Y

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome Y:2786855-2787699

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000383070

ENSP00000372547

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005516	calmodulin binding
GO:0008134	transcription factor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007548	sex differentiation
GO:0030154	cell differentiation
GO:0030238	male sex determination
GO:0045893	positive regulation of transcription, DNA-templated
GO:2000020	positive regulation of male gonad development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016607	nuclear speck

Orthologs

No orthologs found for this gene

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

KEGG

INOH

PID NCI

ar_tf_pathway

Regulation of Androgen receptor activity

Cross-References

SwissProt

Q05066

TrEMBL

A7WPU8 Q6J4J1

UniProt Splice Variant

Entrez Gene

6736

UniGene

Hs.1992

RefSeq

NM_003140

HUGO

HGNC:11311

OMIM

480000

CCDS

CCDS14772

HPRD

IMGT

EMBL

AM884747 AM884750 AY601852 AY601853 AY601854 AY601855 AY601856 AY601857 AY601859 AY601860 BC074923 BC074924 CH471115 DQ086141 FN568067 FN568068 FN568069 FN568070 FN568071 FN568073 FN568074 FN568075 FN568076 FN568077 FN568078 FN568079 FN568080 FN568081 FN568082 FN568083 FN568084 FN568085 FN568086 FN568087 FN568088 HM241133 HM241136 HM241142 HM362426 JQ811904 JQ811905 JQ811906 JQ811907 JQ811908 JQ811909 JQ811910 JQ811911 JQ811913 JQ811915 JQ811916 JQ811917 JQ811919 JQ811922 JQ811923 JQ811924 JQ811925 JQ811926 JQ811927 JQ811928 JQ811929 JQ811930 JQ811933 JQ811934 KF413436 KF413440 L08063 L10101 L10102 S53156 S56543 X53772 X96421

GenPept

AAA16878 AAA60590 AAA60591 AAB25008 AAB25716 AAH74923 AAH74924 AAT39011 AAT39012 AAT39013 AAT39014 AAT39015 AAT39016 AAT39018 AAT39019 AAY88212 ADJ00507 ADJ00510 ADJ00516 ADJ37112 AFG33929 AFG33930 AFG33931 AFG33932 AFG33933 AFG33934 AFG33935 AFG33936 AFG33937 AFG33938 AFG33939 AFG33940 AFG33942 AFG33944 AFG33945 AFG33946 AFG33947 AFG33948 AFG33949 AFG33950 AFG33951 AFG33952 AFG33954 AFG33955 AGZ62969 AGZ62973 CAA37790 CAA65281 CAP05198 CAP05201 CBH40188 CBH40189 CBH40190 CBH40191 CBH40192 CBH40194 CBH40195 CBH40196 CBH40197 CBH40198 CBH40199 CBH40200 CBH40201 CBH40202 CBH40203 CBH40204 CBH40205 CBH40206 CBH40207 CBH40208 CBH40209 EAX02769

RNA Seq Atlas

6736