InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HSPA2

Summary

InnateDB Gene

IDBG-9191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA2

Gene Name

heat shock 70kDa protein 2

Synonyms

HSP70-2; HSP70-3

Species

Homo sapiens

Ensembl Gene

ENSG00000126803

Encoded Proteins

IDBP-9193

heat shock 70kDa protein 2

IDBP-241038

heat shock 70kDa protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:64535905-64546173

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000247207	ENSP00000247207
ENST00000394709	ENSP00000378199
ENST00000554883

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0051082	unfolded protein binding
GO:0051861	glycolipid binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0006986	response to unfolded protein
GO:0007140	male meiosis
GO:0007141	male meiosis I
GO:0007286	spermatid development
GO:0031662	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
GO:0042026	protein refolding
GO:0070194	synaptonemal complex disassembly
GO:0090084	negative regulation of inclusion body assembly

Cellular Component

GO:0000795	synaptonemal complex
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0009986	cell surface
GO:0016020	membrane
GO:0036128	CatSper complex
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000059970

View Gene Order

Pathways

NETPATH

REACTOME

REACT_75792

Meiotic synapsis pathway

REACT_120956

Cellular responses to stress pathway

REACT_200780

Regulation of HSF1-mediated heat shock response pathway

REACT_200624

Attenuation phase pathway

REACT_115566

Cell Cycle pathway

REACT_200775

HSF1-dependent transactivation pathway

REACT_200819

Cellular response to heat stress pathway

REACT_111183

Meiosis pathway

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04612

Antigen processing and presentation pathway

hsa04144

Endocytosis pathway

hsa03040

Spliceosome pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

hsa05145

Toxoplasmosis pathway

INOH

PID NCI

Cross-References

SwissProt

P54652

TrEMBL

A0A024R6B5

UniProt Splice Variant

Entrez Gene

3306

UniGene

Hs.432648 Hs.741667

RefSeq

NM_021979

HUGO

HGNC:5235

OMIM

140560

CCDS

CCDS9766

HPRD

IMGT

EMBL

AH006615 BC001752 BC036107 BT009815 CH471061 DQ489378 L26336 U56725

GenPept

AAA52698 AAC50076 AAD11466 AAH01752 AAH36107 AAP88817 ABE96830 EAW80864 EAW80865

RNA Seq Atlas

3306