Version 5.4
Bos taurus Gene: KCNA1
Summary
InnateDB Gene IDBG-648416.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNA1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016646
Encoded Proteins
IDBP-701164
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111262:
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:105663225-105664712
Strand Reverse strand
Band
Transcripts
ENSBTAT00000022142 ENSBTAP00000022142
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0044224 juxtaparanode region of axon
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111262
View Gene Order
ENSMUSG00000047976
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
REACT_202800
Potassium Channels pathway
REACT_259290
Neuronal System pathway
REACT_199077
Voltage gated Potassium channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MLD6
UniProt Splice Variant
Entrez Gene 538703
UniGene
RefSeq XM_005198456 XM_005207204
HUGO HGNC:6218
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014524
GenPept
RNA Seq Atlas 538703

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca