InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CBX3

Summary

InnateDB Gene

IDBG-647246.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBX3

Gene Name

chromobox protein homolog 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005540

Encoded Proteins

IDBP-700084

chromobox protein homolog 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122565:
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5\' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:264298-264843

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000007283

ENSBTAP00000007283

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:1990226	histone methyltransferase binding

Biological Process

GO:0045892

negative regulation of transcription, DNA-templated

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005719	nuclear euchromatin
GO:0005720	nuclear heterochromatin
GO:0005819	spindle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000122565

View Gene Order

ENSMUSG00000029836

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_2204

RNA Polymerase I Chain Elongation pathway

REACT_1309

RNA Polymerase I Transcription pathway

REACT_21352

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1N1S3

UniProt Splice Variant

Entrez Gene

539788

UniGene

RefSeq

NM_001101198

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02000012

GenPept

RNA Seq Atlas

539788