Version 5.4
Bos taurus Gene: TGFB3
Summary
InnateDB Gene IDBG-646881.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFB3
Gene Name transforming growth factor beta-3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012004
Encoded Proteins
IDBP-699722
transforming growth factor beta-3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119699:
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:88242180-88266347
Strand Reverse strand
Band
Transcripts
ENSBTAT00000015925 ENSBTAP00000015925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0034713 type I transforming growth factor beta receptor binding
GO:0042802 identical protein binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007435 salivary gland morphogenesis
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 negative regulation of macrophage cytokine production
GO:0016049 cell growth
GO:0022601 menstrual cycle phase
GO:0030501 positive regulation of bone mineralization
GO:0030879 mammary gland development
GO:0032570 response to progesterone
GO:0032967 positive regulation of collagen biosynthetic process
GO:0040007 growth
GO:0043065 positive regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043932 ossification involved in bone remodeling
GO:0045216 cell-cell junction organization
GO:0045740 positive regulation of DNA replication
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0050714 positive regulation of protein secretion
GO:0051491 positive regulation of filopodium assembly
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0070483 detection of hypoxia
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000119699
View Gene Order
ENSMUSG00000021253
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_163906
ECM proteoglycans pathway
REACT_604
Hemostasis pathway
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_196606
ECM proteoglycans pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04144
Endocytosis pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05200
Pathways in cancer pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05140
Leishmaniasis pathway
hsa05146
Amoebiasis pathway
hsa05144
Malaria pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05145
Toxoplasmosis pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu05211
Renal cell carcinoma pathway
mmu04350
TGF-beta signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu04110
Cell cycle pathway
mmu04010
MAPK signaling pathway pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05212
Pancreatic cancer pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu05140
Leishmaniasis pathway
mmu05146
Amoebiasis pathway
mmu05144
Malaria pathway
mmu05145
Toxoplasmosis pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
INOH website
GPCR signaling pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
alk1pathway
ALK1 signaling events
Cross-References
SwissProt
TrEMBL A6QP91
UniProt Splice Variant
Entrez Gene 538957
UniGene Bt.54513
RefSeq NM_001101183 XM_005212206 XM_005212207
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149207 DAAA02029647
GenPept AAI49208
RNA Seq Atlas 538957

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca