InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LEO1

Summary

InnateDB Gene

IDBG-646652.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LEO1

Gene Name

RNA polymerase-associated protein LEO1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013830

Encoded Proteins

IDBP-699476

RNA polymerase-associated protein LEO1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166477:
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:58507402-58543453

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018400

ENSBTAP00000018400

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001711	endodermal cell fate commitment
GO:0006378	mRNA polyadenylation
GO:0010390	histone monoubiquitination
GO:0019827	stem cell maintenance
GO:0031442	positive regulation of mRNA 3'-end processing
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523	histone H2B ubiquitination
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter