InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MYO5A

Summary

InnateDB Gene

IDBG-646647.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO5A

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006489

Encoded Proteins

IDBP-699470

myosin VA (heavy chain 12, myoxin)

IDBP-699471

myosin VA (heavy chain 12, myoxin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197535:
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:58026028-58152577

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008516	ENSBTAP00000008516
ENSBTAT00000063531	ENSBTAP00000054970

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0017137	Rab GTPase binding
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006582	melanin metabolic process
GO:0006887	exocytosis
GO:0007268	synaptic transmission
GO:0007601	visual perception
GO:0008152	metabolic process
GO:0016192	vesicle-mediated transport
GO:0030048	actin filament-based movement
GO:0030073	insulin secretion
GO:0030318	melanocyte differentiation
GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031987	locomotion involved in locomotory behavior
GO:0032252	secretory granule localization
GO:0032400	melanosome localization
GO:0032402	melanosome transport
GO:0032869	cellular response to insulin stimulus
GO:0042438	melanin biosynthetic process
GO:0042476	odontogenesis
GO:0042552	myelination
GO:0042640	anagen
GO:0042759	long-chain fatty acid biosynthetic process
GO:0048066	developmental pigmentation
GO:0050808	synapse organization
GO:0051643	endoplasmic reticulum localization
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0001726	ruffle
GO:0001750	photoreceptor outer segment
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005882	intermediate filament
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030141	secretory granule
GO:0032593	insulin-responsive compartment
GO:0035371	microtubule plus-end
GO:0042470	melanosome
GO:0042641	actomyosin
GO:0043025	neuronal cell body