Version 5.4
Bos taurus Gene: ADAM10
Summary
InnateDB Gene IDBG-646594.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM10
Gene Name Disintegrin and metalloproteinase domain-containing protein 10
Synonyms ADAM 10
Species Bos taurus
Ensembl Gene ENSBTAG00000005481
Encoded Proteins
IDBP-699415
Disintegrin and metalloproteinase domain-containing protein 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18981120
[Homo sapiens] ADAM10 associates with tetraspanins and regulates cleavage of TNF (TNF-alpha) and EGF (epidermal growth factor).
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137845:
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:51598073-51739153
Strand Forward strand
Band
Transcripts
ENSBTAT00000044627 ENSBTAP00000042110
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006468 protein phosphorylation
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007162 negative regulation of cell adhesion
GO:0007219 Notch signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010820 positive regulation of T cell chemotaxis
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0034612 response to tumor necrosis factor
GO:0042117 monocyte activation
GO:0051088 PMA-inducible membrane protein ectodomain proteolysis
GO:0051089 constitutive protein ectodomain proteolysis
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
GO:0097038 perinuclear endoplasmic reticulum
GO:0097197 tetraspanin-enriched microdomain
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137845
View Gene Order
ENSMUSG00000054693
View Gene Order
Pathways
NETPATH
REACTOME
REACT_207202
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_221284
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_227813
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_220704
Signaling by NOTCH pathway
REACT_213874
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_223425
Extracellular matrix organization pathway
REACT_221028
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_222620
Collagen degradation pathway
REACT_201925
Degradation of the extracellular matrix pathway
REACT_225696
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_221597
Signaling by NOTCH3 pathway
REACT_204419
Signaling by NOTCH1 in Cancer pathway
REACT_214353
Signal Transduction pathway
REACT_225370
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_203140
Axon guidance pathway
REACT_225877
Signaling by NOTCH1 pathway
REACT_220326
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_246661
EPH-ephrin mediated repulsion of cells pathway
REACT_227244
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_220466
Signaling by NOTCH4 pathway
REACT_225248
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_204471
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_215347
Signaling by NOTCH2 pathway
REACT_207087
Disease pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_9417
Signaling by EGFR pathway
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_118636
Signaling by NOTCH4 pathway
REACT_118862
Signaling by NOTCH3 pathway
REACT_160205
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_150401
Collagen degradation pathway
REACT_160089
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_160106
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_111045
Developmental Biology pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_118779
Extracellular matrix organization pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_18266
Axon guidance pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_116125
Disease pathway
REACT_196643
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_189085
Disease pathway
REACT_206066
Extracellular matrix organization pathway
REACT_196589
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_243590
EPH-ephrin mediated repulsion of cells pathway
REACT_242976
Signaling by EGFR pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199384
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_199412
Signaling by NOTCH2 pathway
REACT_199413
Signaling by NOTCH3 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_199411
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199404
Signaling by NOTCH4 pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_261444
Axon guidance pathway
REACT_196638
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
REACT_196591
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa05010
Alzheimer's disease pathway
mmu05010
Alzheimer's disease pathway
INOH
INOH website
Notch signaling pathway pathway
INOH website
Notch signaling pathway pathway
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.49218
RefSeq NM_174496
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca