Version 5.4
Bos taurus Gene: TLN2
Summary
InnateDB Gene IDBG-646546.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLN2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003667
Encoded Proteins
IDBP-699365
talin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171914:
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:47303876-47796327
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061376 ENSBTAP00000053521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005158 insulin receptor binding
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007155 cell adhesion
Cellular Component
GO:0001726 ruffle
GO:0005856 cytoskeleton
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000171914
View Gene Order
ENSMUSG00000052698
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04510
Focal adhesion pathway
mmu04510
Focal adhesion pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MQI1
UniProt Splice Variant
Entrez Gene 528252
UniGene Bt.31841
RefSeq XM_002690844 XM_005193652 XM_005193653 XM_005193654 XM_606666
HUGO HGNC:15447
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02028757 DAAA02028758 DAAA02028759 DAAA02028760 DAAA02028761 DAAA02028762 DAAA02028763 DAAA02028764 DAAA02028765
GenPept
RNA Seq Atlas 528252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca