InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACIN1

Summary

InnateDB Gene

IDBG-645833.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACIN1

Gene Name

ACIN1 protein; Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011571

Encoded Proteins

IDBP-698601

apoptotic chromatin condensation inducer in the nucleus

IDBP-698602

apoptotic chromatin condensation inducer in the nucleus

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100813:
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:21598911-21637359

Strand

Forward strand

Band

Transcripts

ENSBTAT00000015372	ENSBTAP00000015372
ENSBTAT00000002488	ENSBTAP00000002488

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0030218	erythrocyte differentiation
GO:0030263	apoptotic chromosome condensation
GO:0043065	positive regulation of apoptotic process
GO:0045657	positive regulation of monocyte differentiation
GO:0048025	negative regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0061574	ASAP complex