InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MAP2K5

Summary

InnateDB Gene

IDBG-645481.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP2K5

Gene Name

dual specificity mitogen-activated protein kinase kinase 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000218

Encoded Proteins

IDBP-698185

mitogen-activated protein kinase kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137764:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:14354690-14626128

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000265

ENSBTAP00000000265

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups