InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DAPK3

Summary

InnateDB Gene

IDBG-644327.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAPK3

Gene Name

death-associated protein kinase 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020417

Encoded Proteins

IDBP-696962

death-associated protein kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167657:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:21265025-21278270

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027209

ENSBTAP00000027209

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043522	leucine zipper domain binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0009103	lipopolysaccharide biosynthetic process
GO:0017148	negative regulation of translation
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0071346	cellular response to interferon-gamma
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:0097190	apoptotic signaling pathway