Version 5.4
Bos taurus Gene: SIRT6
Summary
InnateDB Gene IDBG-644302.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT6
Gene Name NAD-dependent deacetylase sirtuin-6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019909
Encoded Proteins
IDBP-696937
NAD-dependent deacetylase sirtuin-6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077463:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:21079144-21087377
Strand Forward strand
Band
Transcripts
ENSBTAT00000026521 ENSBTAP00000026521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0070403 NAD+ binding
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0070932 histone H3 deacetylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005724 nuclear telomeric heterochromatin
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000077463
View Gene Order
ENSMUSG00000034748
View Gene Order
Cross-References
SwissProt
TrEMBL A5D7K6
UniProt Splice Variant
Entrez Gene 535416
UniGene Bt.20024
RefSeq NM_001098084 XM_005208958 XM_005208959 XM_005208960 XM_005208961
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140592 DAAA02019617
GenPept AAI40593
RNA Seq Atlas 535416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca