Bos taurus Gene: TYMS | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-644129.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | TYMS | ||||||||||
Gene Name | thymidylate synthase | ||||||||||
Synonyms | TS | ||||||||||
Species | Bos taurus | ||||||||||
Ensembl Gene | ENSBTAG00000007003 | ||||||||||
Encoded Proteins |
thymidylate synthase
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176890:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 24:35935176-35945792 | ||||||||||
Strand | Forward strand | ||||||||||
Band | |||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||
NETPATH | |||||||||||
REACTOME |
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
Pyrimidine biosynthesis pathway
Metabolism of nucleotides pathway
Mitotic G1-G1/S phases pathway
G1/S Transition pathway
Cell Cycle pathway
Pyrimidine metabolism pathway
Cell Cycle, Mitotic pathway
Metabolism pathway
Pyrimidine biosynthesis pathway
Cell Cycle, Mitotic pathway
Pyrimidine metabolism pathway
Cell Cycle pathway
Metabolism pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
Metabolism of nucleotides pathway
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KEGG |
Pyrimidine metabolism pathway
One carbon pool by folate pathway
Pyrimidine metabolism pathway
One carbon pool by folate pathway
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INOH |
Folate metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
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PID NCI |
E2F transcription factor network
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Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | |||||||||||
UniGene | Bt.7738 | ||||||||||
RefSeq | NM_001037816 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | |||||||||||
GenPept | |||||||||||
RNA Seq Atlas | |||||||||||