Version 5.4
Bos taurus Gene: WHSC1
Summary
InnateDB Gene IDBG-643914.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WHSC1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007986
Encoded Proteins
IDBP-696522
Wolf-Hirschhorn syndrome candidate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109685:
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:109784642-109826922
Strand Forward strand
Band
Transcripts
ENSBTAT00000010497 ENSBTAP00000010497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0003149 membranous septum morphogenesis
GO:0003289 atrial septum primum morphogenesis
GO:0003290 atrial septum secundum morphogenesis
GO:0016568 chromatin modification
GO:0032259 methylation
GO:0034968 histone lysine methylation
GO:0060348 bone development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000109685
View Gene Order
ENSMUSG00000057406
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
hsa00310
Lysine degradation pathway
mmu00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MMY4
UniProt Splice Variant
Entrez Gene 540769
UniGene Bt.37857
RefSeq XM_002688452 XM_005198720 XM_005208303 XM_005208305 XM_613048
HUGO HGNC:12766
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018575
GenPept
RNA Seq Atlas 540769

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca