Version 5.4
Bos taurus Gene: FGFRL1
Summary
InnateDB Gene IDBG-643853.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGFRL1
Gene Name fibroblast growth factor receptor-like 1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000027464
Encoded Proteins
IDBP-696446
fibroblast growth factor receptor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127418:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:109131152-109133968
Strand Forward strand
Band
Transcripts
ENSBTAT00000039444 ENSBTAP00000039238
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0001501 skeletal system development
GO:0003179 heart valve morphogenesis
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0060412 ventricular septum morphogenesis
GO:0060539 diaphragm development
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000127418
View Gene Order
ENSMUSG00000008090
View Gene Order
Cross-References
SwissProt
TrEMBL F1MQI5
UniProt Splice Variant
Entrez Gene 532327
UniGene Bt.21008
RefSeq NM_001205996
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018537
GenPept
RNA Seq Atlas 532327

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca