Version 5.4
Bos taurus Gene: BT.88926
Summary
InnateDB Gene IDBG-643590.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.88926
Gene Name phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000026290
Encoded Proteins
IDBP-696153
phosphatidylinositol 3-kinase catalytic subunit type 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22170068
[Homo sapiens] Class III phosphatidylinositol 3-kinases (PI3K) are required for downstream ARF6 regulation of CpG oligodeoxynucleotide uptake and thus have a role in TLR9-mediated immune signalling.
PMID 22170068
[Mus musculus] Class III phosphatidylinositol 3-kinases (PI3K) are required for downstream Arf6 regulation of CpG oligodeoxynucleotide uptake and thus have a role in Tlr9-mediated immune signalling.
PMID 25586187
[Mus musculus] Super-low dose lipopolysaccharide induces inhibitory phosphorylation of Pik3c3 leading to the disruption of endosome-lysosome fusion and low-grade inflammation in innate macrophages; a mechanism that depends on the clearance and relocation of Tollip.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078142:
Gene Information
Type Protein coding
Genomic Location Chromosome 24:14182757-14347226
Strand Reverse strand
Band
Transcripts
ENSBTAT00000037295 ENSBTAP00000037130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0000910 cytokinesis
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0045022 early endosome to late endosome transport
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005770 late endosome
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0016020 membrane
GO:0030496 midbody
GO:0045335 phagocytic vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000078142
View Gene Order
ENSMUSG00000033628
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_120918
Synthesis of PIPs at the late endosome membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_111217
Metabolism pathway
REACT_239142
Innate Immune System pathway
REACT_198975
Synthesis of PIPs at the early endosome membrane pathway
REACT_198972
Synthesis of PIPs at the late endosome membrane pathway
REACT_198970
Synthesis of PIPs at the Golgi membrane pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_240139
PI3K Cascade pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_188643
Phospholipid metabolism pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04140
Regulation of autophagy pathway
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04145
Phagosome pathway
mmu04140
Regulation of autophagy pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
mmu04145
Phagosome pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MTL5
UniProt Splice Variant
Entrez Gene 534815
UniGene Bt.48739
RefSeq NM_001099067 XM_005223986
HUGO HGNC:8974
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02056290
GenPept
RNA Seq Atlas 534815

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca